In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains
| Autor: | Masakatsu Tsuji, Tsukasa Ito-Horiyama, Yoshinori Yamano, Akinobu Ito, Naoki Kohira, Takafumi Sato, Rio Nakamura, Stephen Rittenhouse, Joshua West |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Klebsiella pneumoniae 030106 microbiology Cephalosporin Siderophores Microbial Sensitivity Tests Enterobacter aerogenes beta-Lactamases Epidemiology and Surveillance Microbiology 03 medical and health sciences Bacterial Proteins Enterobacteriaceae polycyclic compounds medicine Humans Pharmacology (medical) Pharmacology biology Escherichia coli Proteins biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents Cephalosporins Citrobacter freundii Infectious Diseases Carbapenems Serratia marcescens Enterobacter cloacae |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 60:729-734 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01695-15 |
| Popis: | S-649266 is a novel siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. Two sets of clinical isolate collections were used to evaluate the antimicrobial activity of S-649266 against Enterobacteriaceae . These sets included 617 global isolates collected between 2009 and 2011 and 233 β-lactamase-identified isolates, including 47 KPC-, 49 NDM-, 12 VIM-, and 8 IMP-producers. The MIC 90 values of S-649266 against the first set of Escherichia coli , Klebsiella pneumoniae , Serratia marcescens , Citrobacter freundii , Enterobacter aerogenes , and Enterobacter cloacae isolates were all ≤1 μg/ml, and there were only 8 isolates (1.3%) among these 617 clinical isolates with MIC values of ≥8 μg/ml. In the second set, the MIC values of S-649266 were ≤4 μg/ml against 109 strains among 116 KPC-producing and class B (metallo) carbapenemase-producing strains. In addition, S-649266 showed MIC values of ≤2 μg/ml against each of the 13 strains that produced other types of carbapenemases such as SME, NMC, and OXA-48. The mechanisms of the decreased susceptibility of 7 class B carbapenemase-producing strains with MIC values of ≥16 μg/ml are uncertain. This is the first report to demonstrate that S-649266, a novel siderophore cephalosporin, has significant antimicrobial activity against Enterobacteriaceae , including strains that produce carbapenemases such as KPC and NDM-1. |
| Databáze: | OpenAIRE |
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