A critical contribution of both CD28 and ICOS in the adjuvant activity of Neisseria meningitidis H44/76 LPS and lpxL1 LPS

Autor: Kiki Tesselaar, Peter van der Ley, Liana Steeghs, Mariëtte A. Oosterwegel, Elise H. R. Schrijver, Andries van Mourik, Miranda E.A.T. van Berkel
Rok vydání: 2007
Předmět:
Antigens
Differentiation
T-Lymphocyte
Lipopolysaccharides
Lipopolysaccharide
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Meningococcal Vaccines
Neisseria meningitidis
medicine.disease_cause
Microbiology
Inducible T-Cell Co-Stimulator Protein
Mice
chemistry.chemical_compound
Adjuvants
Immunologic
CD28 Antigens
medicine
Animals
Mice
Knockout
Molecular Structure
General Veterinary
General Immunology and Microbiology
biology
Polysaccharides
Bacterial
Public Health
Environmental and Occupational Health
Wild type
CD28
Dendritic cell
biology.organism_classification
Antibodies
Bacterial
Mice
Inbred C57BL
Vaccination
Infectious Diseases
chemistry
Immunoglobulin G
Models
Animal
Immunology
Molecular Medicine
lipids (amino acids
peptides
and proteins)
Neisseriaceae
Adjuvant
Bacterial Outer Membrane Proteins
Zdroj: Vaccine. 25:4681-4688
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2007.04.016
Popis: The development of novel vaccines against Neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxL1 LPS which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (H44/76) LPS. We investigated the costimulation requirements for the adjuvant activity of both forms of LPS by immunizing CD28-, ICOS- and B7.1/2/ICOS-deficient mice. Both ICOS and CD28 appeared essential for optimal adjuvant activity of H44/76 LPS or lpxL1 LPS. Interestingly, ICOS-mediated costimulation predominates in the adjuvant activity of lpxL1 LPS, while both ICOS and CD28 are required for H44/76 LPS adjuvant activity.
Databáze: OpenAIRE
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