Serum depletion of corticosteroid binding activities, an early marker of human septic shock
| Autor: | Hassen Zouaghi, L. Savu, Emmanuel A. Nunez, Alain Carli |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone medicine.drug_class Biophysics Inflammation Endogeny Biochemistry Serum depletion Transcortin Internal medicine Medicine Humans Molecular Biology Progesterone biology business.industry Septic shock Haptoglobin Cell Biology medicine.disease Shock Septic Thyroxine binding prealbumin Kinetics Endocrinology Immunology biology.protein Corticosteroid medicine.symptom business Corticosterone |
| Zdroj: | Biochemical and biophysical research communications. 102(1) |
| ISSN: | 0006-291X |
| Popis: | We report that human sera within 24 hours after the onset of septic shock are virtually depleted of the corticosteroid binding activities characteristic for transcortin. By contrast, transcortin activities are not changed significantly in cases of acute inflammation, though septic shock and inflammatory sera are comparable in other respects: they show similar responses of their haptoglobin, thyroxine binding prealbumin, endogenous cortisol and progesterone levels. The physiological meaning and clinical interest of these results are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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