Unusual MRI findings in an immunocompetent patient with EBV encephalitis: a case report
| Autor: | Paola Di Carlo, Giuseppina Capra, Marcello Trizzino, Giovanni Mazzola, Lucina Titone, Daniela Pistoia, Piero Colletti, Caterina Sarno |
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| Přispěvatelé: | Di Carlo, P, Trizzino, M, Titone Lanza Di Scalea, L, Capra, G, Colletti, P, Mazzola, G, Pistoia, D, Sarno, C |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Settore MED/07 - Microbiologia E Microbiologia Clinica Epstein-Barr virus encephalitis MRI Diffusion-weighted imaging lcsh:Medical technology Mononucleosis Settore MED/17 - Malattie Infettive encephalitis Central nervous system Case Report medicine.disease_cause White matter Immunocompromised Host Neuroimaging medicine Humans Epstein-Barr virus Radiology Nuclear Medicine and imaging Infectious Mononucleosis medicine.diagnostic_test business.industry Settore MED/37 - Neuroradiologia Magnetic resonance imaging medicine.disease Epstein–Barr virus Magnetic Resonance Imaging medicine.anatomical_structure lcsh:R855-855.5 Radiology Nuclear Medicine and imaging Diffusion-weighted imaging business Encephalitis Diffusion MRI MRI |
| Zdroj: | BMC Medical Imaging BMC Medical Imaging, Vol 11, Iss 1, p 6 (2011) Europe PubMed Central |
| ISSN: | 1471-2342 |
| Popis: | Blackground It is well-known that Epstein-Barr virus (EBV) can affect the central nervous system (CNS). Case presentation Herein the authors report unusual timely Magnetic Resonance Imaging (MRI) brain scan findings in an immunocompetent patient with EBV encephalitis. Diffusion weighted MRI sequence performed during the acute phase of the disease was normal, whereas the Fast Relaxation Fast Spin Echo T2 image showed diffuse signal intensity changes in white matter. The enhancement pattern suggested an inflammatory response restricted to the brain microcirculation. Acyclovir and corticosteroid therapy was administered. After three weeks, all signal intensities returned to normal and the patient showed clinical recovery. Conclusion This report demonstrates that EBV in an immunocompetent adult can present with diffuse, reversible brain white matter involvement in the acute phase of mononucleosis. Moreover, our case suggests that a negative DWI sequence is associated with a favorable improvement in severe EBV CNS infection. More extensive studies are needed to assess what other instrumental data can help to distinguish viral lesions from other causes in the acute phase of disease. |
| Databáze: | OpenAIRE |
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