Cognitive Reserve and Executive Functions in Adults with Type 2 Diabetes
| Autor: | Paloma Roa-Rojas, Paola Peña-González, Alejandra Mondragón-Maya, Juan Silva-Pereyra |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism Type 2 diabetes Neuropsychological Tests Audiology Diseases of the endocrine glands. Clinical endocrinology Executive Function Cognition Leisure Activities Endocrinology Cognitive Reserve Humans Verbal fluency test Medicine Cognitive Dysfunction Prospective Studies Effects of sleep deprivation on cognitive performance Mexico Aged Cognitive reserve Aged 80 and over Depression business.industry Multilevel model Brain Middle Aged RC648-665 medicine.disease Executive functions Cross-Sectional Studies Diabetes Mellitus Type 2 Regression Analysis Female Analysis of variance business Research Article |
| Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2020 (2020) |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | Background. Adults with type two diabetes mellitus (DM2) show cognitive deficits within the executive function domain. The detrimental effects of DM2 over executive function (EF) performance may be mediated by factors such as cognitive reserve (CR). CR mediates cognitive performance by delaying the appearance of clinical symptoms from subjacent brain pathology or attenuating the severity of such symptoms. Our main goal was to study the effects of CR on executive functions of adults with DM2. Methods. Data from a total of 1,034 adults were included (362 women, 672 men). Subjects were categorized into four groups: subjects with DM2 and high CR ( n = 235 ), control subjects with high CR ( n = 265 ), subjects with DM2 and low CR ( n = 298 ), and control subjects with low CR ( n = 236 ). CR was quantified through 3 proxies: education, occupational complexity, and leisure activities. Executive functions were evaluated through visual scanning, verbal fluency, and backwards counting tasks. First, a series of four one-way ANOVAs was performed where group was included as a between-subject factor and executive function as a dependent variable. Second, a hierarchical multiple regression analysis was conducted to assess the weight of each CR proxy on EF performance. Results. CR level significantly affected all executive function scores independently of the diabetes status. Hierarchical regression analyses indicated that years of education accounted for most of the variance in the model for executive function performance. In this study, we found that there is a significant effect of CR on executive function performance of DM2 subjects and education is the most important CR proxy. |
| Databáze: | OpenAIRE |
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