Dry Those Crying Eyes: The Role of Depression and Antidepressants in Dry Eye Disease
| Autor: | Jeffrey J. Rakofsky, Sanford I Rakofsky, Boadie W. Dunlop |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Crying Depression Disease Severity of Illness Index Antidepressive Agents law.invention Clinical trial Psychiatry and Mental health Systematic review Randomized controlled trial Serotonin inhibitor law Internal medicine Medicine Antidepressant Humans Pharmacology (medical) Dry Eye Syndromes medicine.symptom business Depression (differential diagnoses) Randomized Controlled Trials as Topic |
| Zdroj: | Journal of clinical psychopharmacology. 41(3) |
| ISSN: | 1533-712X |
| Popis: | Purpose/background Several clinic-based and large population studies have associated a depression diagnosis or depression severity with dry eye disease (DED) or symptoms. On the other hand, several other large population studies have found that antidepressant use was also associated with DED. Unfortunately, many of the studies finding associations between depression and DED did not control for concomitant antidepressant use, whereas the ones that found associations between antidepressant use and DED did not control for severity of depression or other psychiatric indications for selective serotonin inhibitor use. The purpose of this review was to identify whether depression and antidepressants play an independent role from one another in the onset of DED. Methods/procedures A systematic literature review was conducted searching for DED studies that adjusted for concomitant antidepressant use in depressed patients, that adjusted for depressive symptoms in patients taking antidepressants, and that enrolled depressed patients who were not taking psychiatric medications at the time of the study. Additionally, the prescribing information of marketed antidepressants was reviewed to determine rates of dry eyes reported during clinical trials. Findings/results The literature review initially identified 43 studies with 13 fitting the inclusion criteria. Although these studies varied in their quality, 7 revealed statistically significant associations between depression and DED, whereas 7, including 1 randomized trial, revealed significant associations between antidepressants and DED. Sixteen percent of the antidepressant package inserts inspected reported DED symptoms as an infrequent risk. Implications/conclusions This review suggests that independent of one another, both depression and antidepressant use are associated with DED. |
| Databáze: | OpenAIRE |
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