Commentary: Caveats in the screening and management of cytomegalovirus retinitis in human immune deficiency virus and non-human immune deficiency virus infected patients
| Autor: | Niha Z Khatib, Sarvesh Tiwari, Sumita Phatak, Rohit Modi, Anand Subramanyam, Bindiya Doshi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Visual acuity Adolescent Congenital cytomegalovirus infection Retinitis Cytomegalovirus India HIV Infections Antiviral Agents Immunocompromised Host Young Adult lcsh:Ophthalmology Maintenance therapy medicine Humans Special Focus on Ocular Inflammation Original Article Child Retrospective Studies Leukemia business.industry Cancer Retrospective cohort study Middle Aged medicine.disease Ophthalmology lcsh:RE1-994 Cytomegalovirus Retinitis Commentary Etiology Female Cytomegalovirus retinitis medicine.symptom business |
| Zdroj: | Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 69, Iss 3, Pp 623-628 (2021) |
| ISSN: | 1998-3689 0301-4738 |
| Popis: | Purpose: The aim of this study was to describe the clinical features, course, and clinical outcomes of eyes with cytomegalovirus (CMV) retinitis in immunosuppressed patients of different etiologies. Methods: This was a retrospective observational study from a single ophthalmic tertiary care center. The patients included referrals from the nodal cancer center and the local human immunodeficiency virus (HIV) treatment clinic. Demographics, history, visual acuity, ocular features, treatment protocol, and final visual outcome of patients who were diagnosed with CMV retinitis in the period of five years from 2014 to 2019 were studied. Results: CMV retinitis was diagnosed in 25 eyes of 14 patients. Age of the patients ranged from 11–54 years. Ten (71.43%) patients were male and four (29.57%) were female. Eight of them had acute lymphoblastic leukemia (ALL), four were suffering from HIV infection and one patient each had lymphoma and history of a kidney transplant. The treatment for CMV retinitis ranged from two to sixty weeks depending on disease activity and systemic condition. Three of the patients were on maintenance therapy for ALL at the time of reactivation. Conclusion: Duration of treatment for CMV retinitis in patients of ALL was longer as compared to the other etiologies, and in recurrences, it needed to be continued till the completion of maintenance therapy for ALL. It is prudent to advise regular ophthalmic screening of all immunocompromised patients, as they are at a high risk of developing CMV retinitis. Patients of ALL, especially while on maintenance therapy, should be monitored for possible development or reactivation of CMV retinitis. |
| Databáze: | OpenAIRE |
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