Development and validation of analytical method for determination of simvastatin in capsules

Autor:	Marcos Antônio Fernandes Brandão, Anderson de Oliveira Ferreira, Felipe Cerqueira dos Santos, Nádia Rezende Barbosa Raposo, Urias Pardócimo Vaz, Hudson C. Polonini
Jazyk:	portugalština
Rok vydání:	2011
Předmět:	Detection limit Chromatography medicine.diagnostic_test Analytical chemistry General Chemistry lcsh:Chemistry lcsh:QD1-999 Compounding Spectrophotometry medicine Disease risk simvastatin spectrophotometry Mathematics validation studies
Zdroj:	Química Nova v.34 n.3 2011 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Volume: 34, Issue: 3, Pages: 516-519, Published: 2011 Química Nova, Vol 34, Iss 3, Pp 516-519 (2011) Repositório Institucional da UFJF Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF
Popis:	Simvastatin is an oral anti-hyperlipidemic that has been widely used to reduce the cardiovascular disease risk. There isn't any pharmacopoeic method to assay this drug in capsules. It was proposed and validated a method for determining the content of simvastatin in capsules by UV/visible spectrophotometry (l = 237 nm), a more affordable method for the compounding pharmacy. The method was validated for linearity, specificity, range, accuracy, precision, performance, robustness, and limits of detection and quantification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dcdd24839a1748b0540564dac56677 http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300026 Zobrazit plný text záznamu