Current Treatment Options for Intervertebral Disc Pathologies
| Autor: | Sally Roberts, Stephen M. Eisenstein, Birender Balain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Decompression Spinal stenosis Biomedical Engineering Physical Therapy Sports Therapy and Rehabilitation Degeneration (medical) Intervertebral Disc Degeneration Review Q1 03 medical and health sciences 0302 clinical medicine Back pain Immunology and Allergy Medicine Humans Regeneration Orthopedic Procedures Intervertebral Disc Native structure 030304 developmental biology 0303 health sciences Tissue Engineering business.industry Cartilage Treatment options R735 Intervertebral disc medicine.disease R1 Surgery medicine.anatomical_structure medicine.symptom business RA 030217 neurology & neurosurgery Intervertebral Disc Displacement |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 |
| Popis: | The complex structure of the intervertebral disc within the spine is well suited to its mechanical function. However, it is also prone to degeneration, which is associated with various clinical symptoms and conditions, ranging from disc herniation to back pain to spinal stenosis. Most patients’ conditions are managed conservatively but a small proportion progress to having surgery. This may be decompression (to remove tissue such as the disc, bone, or hypertrophic ligaments impinging on nerves) or fusion of the normally mobile intervertebral joint to immobilize it and so reduce pain. These used to involve fairly major surgical procedures, but in the past decade there has been much progress to make the surgery more refined and less invasive, for example using endoscopic approaches. Simultaneously, the research world has been studying and developing tissue engineering and cellular techniques for attempting to regenerate the intervertebral disc, whether simply the central nucleus pulposus or a complete intricate assembly to replicate the native structure of this and the surrounding annulus fibrosus, cartilage endplate, and bone. To date, none of the complex entities have been trialed, while cellular approaches are easier to utilize, have progressed to clinical trials, and may offer a better solution. |
| Databáze: | OpenAIRE |
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