Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization

Autor:	Moez Bali, Nicole K. McKinnon, Myles H. Akabas
Rok vydání:	2011
Předmět:	Patch-Clamp Techniques Anatomy and Physiology Xenopus lcsh:Medicine Biochemistry Ion Channels Mice Xenopus laevis 0302 clinical medicine Protein structure Molecular Cell Biology lcsh:Science Peptide sequence Alanine 0303 health sciences Multidisciplinary biology Neurochemistry Neurotransmitters Transmembrane protein Electrophysiology Cytochemistry Medicine Membranes and Sorting Neurochemicals Ion Channel Gating Research Article Serotonin Protein subunit Molecular Sequence Data Transfection 03 medical and health sciences Animals Humans Patch clamp Amino Acid Sequence Protein Interactions Biology Ion channel 030304 developmental biology lcsh:R Cell Membrane Membrane Proteins Proteins Gamma-Aminobutyric Acid biology.organism_classification Acetylcholine Protein Structure Tertiary Kinetics HEK293 Cells Cellular Neuroscience Biophysics Oocytes lcsh:Q Receptors Serotonin 5-HT3 Molecular Neuroscience Peptides Sequence Alignment 030217 neurology & neurosurgery Neuroscience
Zdroj:	PLoS ONE PLoS ONE, Vol 7, Iss 4, p e35563 (2012)
ISSN:	1932-6203
Popis:	5-HT3A receptors are pentameric neurotransmitter-gated ion channels in the Cys-loop receptor family. Each subunit contains an extracellular domain, four transmembrane segments (M1, M2, M3, M4) and a 115 residue intracellular loop between M3 and M4. In contrast, the M3M4 loop in prokaryotic homologues is
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dab14056810b1c9738e946f4a8e23c https://pubmed.ncbi.nlm.nih.gov/22539982 Zobrazit plný text záznamu