NRAS Mutation Detected in a Melanoma With Chondroid Stroma: A Case Report With Molecular Evaluation and Literature Review of a Rare Form of Melanoma
| Autor: | Shane P Sweeney, Michael C. Royer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neuroblastoma RAS viral oncogene homolog
Male Skin Neoplasms Dermatology Biology Adenocarcinoma DNA sequencing Pathology and Forensic Medicine GTP Phosphohydrolases 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Stroma medicine Carcinoma Humans Melanoma Aged Cartilaginous Differentiation Membrane Proteins Prostatic Neoplasms Neoplasms Second Primary General Medicine medicine.disease Carcinoma Basal Cell Mutation (genetic algorithm) Mutation Cancer research |
| Zdroj: | The American Journal of dermatopathology. 42(8) |
| ISSN: | 1533-0311 |
| Popis: | Melanoma with cartilaginous differentiation is a rare histologic subtype that has been reported in the literature. It often presents clinically different than conventional melanomas and can be diagnostically challenging. Molecular alterations in previously reported cases have not been published. We present a case of melanoma with chondroid stroma from a 70-year-old man that was found to contain an NRAS mutation (c.182A>G (p.Q61R)) via Illumina TruSight Tumor 15 (TST15) next generation sequencing assay. |
| Databáze: | OpenAIRE |
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