Protein supplements after weight loss do not improve weight maintenance compared with recommended dietary protein intake despite beneficial effects on appetite sensation and energy expenditure: a randomized, controlled, double-blinded trial
| Autor: | Louise Kjølbæk, Lesli H. Larsen, Arne Astrup, Nadja B Søndertoft, Carrie Klestrup Rasmussen, Anja Serena, Lone Brinkmann Sørensen, Janne K. Lorenzen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine media_common.quotation_subject Appetite Medicine (miscellaneous) Recommended Dietary Allowances Body Mass Index Body Weight Maintenance Excretion 03 medical and health sciences Double-Blind Method Weight loss Weight Loss medicine Humans Resting energy expenditure Obesity Food science Meals media_common Meal 030109 nutrition & dietetics Nutrition and Dietetics business.industry Thermogenesis Body Fluid Compartments Fluid compartments Middle Aged Overweight Calcium Dietary Whey Proteins Adipose Tissue Dietary Supplements Body Composition Soybean Proteins Lean body mass Female Dietary Proteins medicine.symptom Energy Metabolism business |
| Zdroj: | The American Journal of Clinical Nutrition. 106:684-697 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.115.129528 |
| Popis: | Background: High-protein diets increase weight loss (WL) during energy restriction; therefore, it has been suggested that additional protein intake may improve weight maintenance (WM) after WL.Objective: We investigated the effect of protein supplements from either whey with or without calcium or soy on WM success after WL compared with that of a control.Design: In a randomized, controlled, double-blinded trial, 220 participants aged 18-60 y with body mass index (in kg/m2) from 27.6 to 40.4 were included. The study was initiated with an 8-wk WL period followed by a 24-wk WM period. During WM, participants consumed the following isocaloric supplements (45-48 g/d): whey and calcium (whey+), whey, soy, or maltodextrin (control). Data were collected at baseline, before WM, and after WM (weeks 0, 8, and 32, respectively) and included body composition, blood biochemistry, and blood pressure. Meal tests were performed to investigate diet-induced-thermogenesis (DIT) and appetite sensation. Compliance was tested by 24-h urinary nitrogen excretion.Results: A total of 151 participants completed the WM period. The control and 3 protein supplements did not result in different mean ± SD weight regains (whey+: 2.19 ± 4.6 kg; whey: 2.01 ± 4.6 kg; soy: 1.76 ± 4.7 kg; and control: 2.23 ± 3.8 kg; P = 0.96), fat mass regains (whey+: 0.46 ± 4.5 kg; whey: 0.11 ± 4.1 kg; soy: 0.15 ± 4.1 kg; and control: 0.54 ± 3.3 kg; P = 0.96), or improvements in lean body mass (whey+: 1.87 ± 1.7 kg; whey: 1.94 ± 1.3 kg; soy: 1.58 ± 1.4 kg; and control: 1.74 ± 1.4 kg; P = 0.50) during WM. Changes in blood pressure and blood biochemistry were not different between groups. Compared with the control, protein supplementation resulted in higher DIT (∼30 kJ/2.5 h) and resting energy expenditure (243 kJ/d) and an anorexigenic appetite-sensation profile.Conclusion: Protein supplementation does not result in improved WM success, or blood biochemistry after WL compared with the effects of normal dietary protein intake (0.8-1.0 g · kg-1 · d-1). This trial was registered at clinicaltrials.gov as NCT01561131. |
| Databáze: | OpenAIRE |
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