Application of transglycosylated stevia and hesperidin as drug carriers to enhance biopharmaceutical properties of poorly-soluble artemisinin
| Autor: | Wai Kiong Ng, Shoucang Shen, Reginald B. H. Tan, Kumaran Letchmanan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
food.ingredient
Glycosylation Biocompatibility 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences Antimalarials 0302 clinical medicine Colloid and Surface Chemistry food Drug Stability Humans Stevia Physical and Theoretical Chemistry Solubility Dissolution Supersaturation Drug Carriers Chromatography Chemistry Food additive Hesperidin Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Artemisinins Bioavailability Drug Liberation Drug delivery Thermodynamics Caco-2 Cells 0210 nano-technology Drug carrier Biotechnology Nuclear chemistry |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 161 |
| ISSN: | 1873-4367 |
| Popis: | Biopharmaceutical properties of poorly water-soluble antimalarial drug, Artemisinin (ART), were improved by formulating amorphous solid dispersions with transglycosylated food additives (Hsp-G and Stevia-G) via co-spray drying. Both the formulated ART/Hsp-G and ART/Stevia-G showed superior dissolution properties with a burst release of more than 95% of drug within 5 min, whereas untreated ART dissolved only 4% in 5min. The supersaturation solubility of the formulated ART was enhanced by 2-fold as compared with untreated counterpart. The storage stability tests indicated that these formulations chemically stable at room temperature and under low humidity ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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