Application of the 'VARICOL' process to the separation of the isomers of the SB-553261 racemate

Autor:	D.S. Ross, G. Pigorini, Gerald J. Terfloth, R.M. Nicoud, Olivier Ludemann-Hombourger
Rok vydání:	2002
Předmět:	Chromatography Chemistry Organic Chemistry Stereoisomerism General Medicine Biochemistry Heterocyclic Compounds 2-Ring Analytical Chemistry chemistry.chemical_compound Pharmaceutical technology Scientific method Simulated moving bed Enantiomer
Zdroj:	Journal of chromatography. A. 947(1)
ISSN:	0021-9673
Popis:	A new continuous chromatographic process (VARICOL) has been presented recently. The basic principle of the new VARICOL process consists of an asynchronous shift of the inlet/outlet lines in a multi-column system on a recycle loop. This process has been used to perform the separation of the optical isomers of the SB-553261 racemate. In this paper, we illustrate that for this specific separation, the VARICOL process is more efficient than the well-known SMB process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d9427b5fd767e4972177dac0f43592 https://pubmed.ncbi.nlm.nih.gov/11873998 Zobrazit plný text záznamu Full Text from ScienceDirect