Dynamic Association between HIV-1 Gag and Membrane Domains
| Autor: | Ian B. Hogue, G. Nicholas Llewellyn, Akira Ono |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
endocrine system Applied Mathematics General Mathematics viruses 030302 biochemistry & molecular biology Lipid microdomain Structural protein Context (language use) Review Article Biology Virology Cell junction Virus 3. Good health Cell biology Cell membrane 03 medical and health sciences medicine.anatomical_structure Membrane Hiv 1 gag medicine 030304 developmental biology |
| Zdroj: | Molecular Biology International |
| ISSN: | 2090-2190 |
| Popis: | HIV-1 particle assembly is driven by the structural protein Gag. Gag binds to and multimerizes on the inner leaflet of the plasma membrane, eventually resulting in formation of spherical particles. During virus spread among T cells, Gag accumulates to the plasma membrane domain that, together with target cell membrane, forms a cell junction known as the virological synapse. While Gag association with plasma membrane microdomains has been implicated in virus assembly and cell-to-cell transmission, recent studies suggest that, rather than merely accumulating to pre-existing microdomains, Gag plays an active role in reorganizing the microdomains via its multimerization activity. In this paper, we will discuss this emerging view of Gag microdomain interactions. Relationships between Gag multimerization and microdomain association will be further discussed in the context of Gag localization to T-cell uropods and virological synapses. |
| Databáze: | OpenAIRE |
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