Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma
| Autor: | Hirofumi Hamada, Rina Takayama, Katarzyna A. Podyma-Inoue, Katsuhito Fujiu, Akiko Kunita, Kazuki Takahashi, Teppei Morikawa, Hiroaki Uchida, Tetsuro Watabe, Hayato Okamoto, Shumpei Ishikawa, Masashi Fukayama, Moegi Sato, Yasuhiro Yoshimatsu, Tsukasa Oshima, Daisuke Komura, Taishi Tomizawa, Takeshi Fukuhara, Mao Komai |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Angiogenesis lcsh:Medicine Article 03 medical and health sciences Mice 0302 clinical medicine Amphiregulin Epidermal growth factor Pancreatic cancer Glioma Cell Line Tumor Biomarkers Tumor Medicine Animals Humans lcsh:Science neoplasms Melanoma Cell Proliferation Mice Knockout Multidisciplinary business.industry lcsh:R Cancer Interleukin-13 receptor medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic 030104 developmental biology Cancer research Interleukin-13 Receptor alpha2 Subunit lcsh:Q business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Malignant melanoma is one of the untreatable cancers in which conventional therapeutic strategies, including chemotherapy, are hardly effective. Therefore, identification of novel therapeutic targets involved in melanoma progression is urgently needed for developing effective therapeutic methods. Overexpression of interleukin-13 receptor α2 (IL13Rα2) is observed in several cancer types including glioma and pancreatic cancer. Although IL13Rα2 is implicated in the progression of various types of cancer, its expression and roles in the malignant melanoma have not yet been elucidated. In the present study, we showed that IL13Rα2 was expressed in approximately 7.5% melanoma patients. While IL13Rα2 expression in human melanoma cells decreased their proliferation in vitro, it promoted in vivo tumour growth and angiogenesis in melanoma xenograft mouse model. We also found that the expression of amphiregulin, a member of the epidermal growth factor (EGF) family, was correlated with IL13Rα2 expression in cultured melanoma cells, xenograft tumour tissues and melanoma clinical samples. Furthermore, expression of amphiregulin promoted tumour growth, implicating causal relationship between the expression of IL13Rα2 and amphiregulin. These results suggest that IL13Rα2 enhances tumorigenicity by inducing angiogenesis in malignant melanoma, and serves as a potential therapeutic target of malignant melanoma. |
| Databáze: | OpenAIRE |
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