Analysis of Genetic Variation of Two NADC30-like Strains of Porcine Reproductive and Respiratory Syndrome Virus in China
| Autor: | Zhai Xinyan, Bo Hou, Jiajun Wu, Zhou Zhi, Yinyi Liu, Zhang Shuo, Xu Qi, Han Tao, Dong yue Wang, Wang Jing, Shengpeng Xin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics medicine.medical_specialty Genetic diversity Traditional medicine biology Phylogenetic tree Porcine reproductive and respiratory syndrome virus biology.organism_classification Homology (biology) Virus Article 03 medical and health sciences 030104 developmental biology Phylogenetics NADC30-like strain Molecular genetics Genetic variation medicine PPRSV |
| Zdroj: | The Open Virology Journal |
| ISSN: | 1874-3579 |
| Popis: | Background: NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012. Objective and Method: To explore the possible genetic diversity of these strains, we sequenced and analyzed the complete genomes of two NADC30-like strains. These isolates shared 95.4% homology with NADC30. Result: The two strains displayed a discontinuous deletion of 131 amino acids in NSP2, mutations of amino acids in GP3 and GP5, and a 3-nucleotide deletion in the 3′ untranslated region. Phylogenetic analysis showed that the two isolates formed a new branch and clustered in a subgroup with NADC30 isolates from North America. Conclusion: We conclude that the above two NADC30-like strains may have been introduced from North America to China, where they acquired new genetic diversity. |
| Databáze: | OpenAIRE |
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