Minor Changes in the Composition and Function of the Gut Microbiota During a 12-Week Whole Grain Wheat or Refined Wheat Intervention Correlate with Liver Fat in Overweight and Obese Adults
| Autor: | Suzan Wopereis, Guido J. E. J. Hooiveld, Mara P H van Trijp, Lydia A. Afman, Diederik Esser, Sophie Schutte, Femke P M Hoevenaars |
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| Rok vydání: | 2021 |
| Předmět: |
Dietary Fiber
Male 0301 basic medicine Flour Medicine (miscellaneous) Overweight Gut flora Voeding Metabolisme en Genomica Feces 0302 clinical medicine Nonalcoholic fatty liver disease fermentation Whole Grains Nutrition and Dietetics biology Fatty liver Middle Aged Metabolism and Genomics Health & Consumer Research Liver Metabolisme en Genomica Nutrition Metabolism and Genomics Female 030211 gastroenterology & hepatology medicine.symptom Metabolic Networks and Pathways Ruminococcaceae medicine.medical_specialty refined wheat Aspartate transaminase AcademicSubjects/MED00060 03 medical and health sciences Voeding Double-Blind Method Internal medicine medicine Humans human Food Health & Consumer Research VLAG Nutrition Aged fatty liver gut microbiota business.industry Biochemical Molecular and Genetic Mechanisms overweight/obesity medicine.disease biology.organism_classification Obesity Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology Endocrinology Alanine transaminase Food Commentary biology.protein AcademicSubjects/SCI00960 whole grain wheat Edible Grain business Biomarkers |
| Zdroj: | The Journal of Nutrition Hepatobiliary Surg Nutr The Journal of Nutrition, 151(3), 491-502 The Journal of Nutrition 151 (2020) 3 |
| ISSN: | 0022-3166 |
| Popis: | Background Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role. Objectives We investigated the effect of WGW compared with RW intervention on the fecal microbiota composition and functionality, and correlated intervention-induced changes in bacteria with changes in liver health parameters in adults with overweight or obesity. Methods We used data of a 12-wk double-blind, randomized, controlled, parallel trial to examine the effects of a WGW (98 g/d) or RW (98 g/d) intervention on the secondary outcomes fecal microbiota composition, predicted microbiota functionality, and stool consistency in 37 women and men (aged 45–70 y, BMI 25–35 kg/m2). The changes in microbiota composition, measured using 16S ribosomal RNA gene sequencing, after a 12-wk intervention were analyzed with nonparametric tests, and correlated with changes in liver fat and circulating concentrations of liver enzymes including alanine transaminase, aspartate transaminase, γ-glutamyltransferase, and serum amyloid A. Results The WGW intervention increased the mean (± SD) relative abundances of Ruminococcaceae_UCG-014 (baseline: 2.2 ± 4.6%, differential change over time (Δ) 0.51 ± 4.2%), Ruminiclostridium_9 (baseline: 0.065 ± 0.11%, Δ 0.054 ± 0.14%), and Ruminococcaceae_NK4A214_group (baseline: 0.37 ± 0.56%, Δ 0.17 ± 0.83%), and also the predicted pathway acetyl-CoA fermentation to butyrate II (baseline: 0.23 ± 0.062%, Δ 0.035 ± 0.059%), compared with the RW intervention (P values |
| Databáze: | OpenAIRE |
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