The influence of anaemia on stroke prognosis and its relation to N-terminal pro-brain natriuretic peptide
| Autor: | S. R. Kristensen, Mads Nybo, Jesper K. Jensen, H. Mickley |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Comorbidity Stress Logistic regression Brain Ischemia Kidney Failure Stress Physiological Predictive Value of Tests Internal medicine Natriuretic Peptide Brain Prevalence medicine Natriuretic peptide Humans Renal Insufficiency cardiovascular diseases Intensive care medicine Stroke Aged Aged 80 and over Heart Failure Troponin T business.industry Anemia Odds ratio Middle Aged Prognosis medicine.disease Peptide Fragments Causality Neurology Regional Blood Flow Predictive value of tests Heart failure Cardiology Female Neurology (clinical) business |
| Zdroj: | Nybo, M, Kristensen, S R, Mickley, H & Jensen, J K 2007, ' The influence of anaemia on stroke prognosis and its relation to N-terminal pro-brain natriuretic peptide. ', European Journal of Eurology, vol. 114, no. 5, pp. 477-82 . Nybo, M, Kristensen, S R, Mickley, H & Jensen, J K 2007, ' The influence of anaemia on stroke prognosis and its relation to N-terminal pro-brain natriuretic peptide ', European Journal of Neurology, vol. 14, no. 5, pp. 477-482 . https://doi.org/10.1111/j.1468-1331.2006.01591.x |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | Udgivelsesdato: 2007-May Anaemia is a negative prognostic factor for patients with heart failure and impaired renal function, but its role in stroke patients is unknown. Furthermore, anaemia has been shown to influence the level of N-terminal pro-brain natriuretic peptide (NT-proBNP), but this is only investigated in patients with heart failure, not in stroke patients. Two-hundred-and-fifty consecutive, well-defined ischemic stroke patients were investigated. Mortality was recorded at 6 months follow-up. Anaemia was diagnosed in 37 patients (15%) in whom stroke severity was worse than in the non-anaemic group, whilst the prevalence of renal affection, smoking and heart failure was lower. At 6 months follow-up, 23 patients were dead, and anaemia had an odds ratio of 4.7 when adjusted for age, Scandinavian Stroke Scale and a combined variable of heart and/or renal failure and/or elevation of troponin T using logistic regression. The median NT-proBNP level in the anaemic group was significantly higher than in the non-anaemic group, and in a multivariate linear regression model, anaemia remained an independent predictor of NT-proBNP. Conclusively, anaemia was found to be a negative prognostic factor for ischemic stroke patients. Furthermore, anaemia influenced the NT-proBNP level in ischemic stroke patients, an important aspect when interpreting NT-proBNP in these patients |
| Databáze: | OpenAIRE |
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