Elemental changes in the hippocampal formation following two different formulas of ketogenic diet: an X-ray fluorescence microscopy study
| Autor: | Joanna Chwiej, Zuzanna Setkowicz, A. Patulska, Rolf Simon, Agnieszka Skoczen, Małgorzata Ciarach, Krzysztof Janeczko |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Topographic and quantitative elemental analysis
Male medicine.medical_specialty medicine.medical_treatment Hippocampus chemistry.chemical_element Hippocampal formation Biochemistry X-ray fluorescence microscopy Inorganic Chemistry Selenium hippocampal formation Metals Heavy Internal medicine medicine Animals Rats Wistar Original Paper Synchrotron radiation Chemistry synchrotron radiation Dentate gyrus Spectrometry X-Ray Emission Ketogenic diet Diet Rats Zinc Endocrinology Elemental analysis ketogenic diet topographic and quantitative elemental analysi Composition (visual arts) Diet Ketogenic Quantitative analysis (chemistry) |
| Zdroj: | Journal of Biological Inorganic Chemistry |
| ISSN: | 0949-8257 |
| DOI: | 10.1007/s00775-015-1306-y |
| Popis: | The main purpose of the following study was the determination of elemental changes occurring within hippocampal formation as a result of high-fat and carbohydrate-restricted ketogenic diet (KD). To realize it, X-ray fluorescence microscopy was applied for topographic and quantitative analysis of P, S, K, Ca, Fe, Cu, Zn and Se in hippocampal formations taken from rats fed with two different KDs and naive controls. The detailed comparisons were done for sectors 1 and 3 of the Ammon's, the dentate gyrus and hilus of dentate gyrus. The results of elemental analysis showed that the KDs induced statistically significant changes in the accumulation of P, K, Ca, Zn and Se in particular areas of hippocampal formation and these alterations strongly depended on the composition of the diets. Much greater influence on the hippocampal areal densities of examined elements was found for the KD which was characterized by a lower content of carbohydrates, higher content of fats and increased proportion of unsaturated fatty acids. The levels of P, K and Zn decreased whilst those of Ca and Se increased as a result of the treatment with the KDs. |
| Databáze: | OpenAIRE |
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