Derivatives of human β-Casein fragments (54–59) exhibit highly potent immunosuppressant activity
| Autor: | L.M. Tripathi, Wahajul Haq, Anju Puri, M. Bhattacharya |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Erythrocytes
medicine.drug_class Immunology Administration Oral chemical and pharmacologic phenomena Peptide Lymphocyte proliferation Pharmacology Biology Immunostimulant Interferon-gamma Mice Immune system medicine Animals Humans Immunology and Allergy Lymphocytes Peptide sequence Cell Proliferation Immunosuppression Therapy chemistry.chemical_classification Immunity Cellular Mice Inbred BALB C Sheep Graft Survival Caseins Biological activity Skin Transplantation Mixed lymphocyte reaction Peptide Fragments Immunity Humoral Amino Acid Substitution Gene Expression Regulation chemistry Biochemistry Humoral immunity Interleukin-4 Lymphocyte Culture Test Mixed Oligopeptides |
| Zdroj: | International Immunopharmacology. 9:1092-1096 |
| ISSN: | 1567-5769 |
| Popis: | Human β-casein fragment (54–59) having the amino acid sequence Val–Glu–Pro–Ile–Pro–Tyr, has shown potent immunostimulant activity. Several analogs of this hexapeptide have been synthesized with modification at the N-terminal region and two analogs, viz. peptide I and peptide II have shown significant immunosuppressant activity in-vivo mouse model. Effect on cell mediated immunity (CMI) and humoral immunity was studied in mouse/SRBC model. Both the peptides failed to stimulate immune response in vivo and showed inhibition of CMI and humoral response to sheep red blood cells (SRBC). Peptides showed inhibition in alloantigen induced lymphocyte proliferation, i.e., mixed lymphocyte reaction (MLR) in vitro . Treatment with peptides inhibited the production of interferon-γ (IFN-γ), and increased the production of interleukin-4 (IL-4) as well as improved the skin graft survival. Cyclosporine a known immunosuppressant showed similar effect on mouse model. Present study thus provides a lead for the development of safe and effective immunosuppressant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect