Contrasting Autonomic and Hemodynamic Effects of Insulin in Healthy Elderly Versus Young Subjects
| Autor: | Martin Hausberg, Robert P. Hoffman, Christine A. Sinkey, Virend K. Somers, Erling A. Anderson, Allyn L. Mark |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Blood Glucose Male Aging medicine.medical_specialty medicine.medical_treatment Vasodilation Autonomic Nervous System Cardiovascular System Insulin resistance Internal medicine Heart rate Internal Medicine Humans Insulin Medicine Aged business.industry Hemodynamics Microneurography Middle Aged medicine.disease Plethysmography medicine.anatomical_structure Endocrinology Blood pressure Vascular resistance medicine.symptom business Vasoconstriction |
| Zdroj: | Hypertension. 29:700-705 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.29.3.700 |
| Popis: | Acute increases in plasma insulin produce both sympathoexcitation and vasodilation in normal young adults. Aging is associated with insulin resistance and may alter the sympathetic or the vascular responses to insulin. Therefore, we assessed sympathetic and vascular responses to acute physiological increases in plasma insulin levels in 10 healthy, normotensive elderly (65±2 years) and 12 normal young (27±1 years) subjects matched for body mass index (25±1 kg/m 2 in both groups). We measured muscle sympathetic nerve activity (microneurography), FBF (plethysmography), heart rate, and blood pressure and calculated forearm vascular resistance and insulin sensitivity (M value) during a 90-minute hyperinsulinemic/euglycemic clamp. M values were 4.3±0.4 mg·kg −1 ·min −1 in the elderly and 8.4±1.4 mg·kg −1 ·min −1 in the young subjects ( P P P P |
| Databáze: | OpenAIRE |
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