| Autor: |
Nikita Katila, Ramesh Duwa, Sunil Bhurtel, Shristi Khanal, Srijan Maharjan, Jee-Heon Jeong, Sooyeun Lee, Dong-Young Choi, Simmyung Yook |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of controlled release : official journal of the Controlled Release Society. 346 |
| ISSN: |
1873-4995 |
| Popis: |
Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. The specific molecular mechanisms through which PD-associated neuronal loss occurs remain unclear, and there is no available effective treatment against PD-related neurodegeneration. Resveratrol (RSV) has exhibited promising neuroprotective effects via antioxidant and anti-inflammatory activity. However, its poor bioavailability in the brain represents a challenge for its application in PD treatment. In this study, we synthesized RSV-loaded PLGA nanoparticles (RSV-PLGA-NPs) conjugated with lactoferrin (Lf) to enhance RSV diffusion into the brain and assessed whether this formulation improved the neuroprotective effects of RSV in experimental PD models. The Lf-conjugated RSV-PLGA-NPs (Lf-RSV-PLGA-NPs) exhibited enhanced internalization into SH-SY5Y and human brain microvascular endothelial cells as compared to RSV-PLGA-NPs and free RSV. Further, Lf-RSV-PLGA-NPs were more effective than RSV-PLGA-NPs and free RSV in attenuating the MPP |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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