Choriocapillaris: Fundamentals and advancements
| Autor: | Srinivas R. Sadda, José-Alain Sahel, K. Bailey Freund, Marie Hélène Errera, Jennifer Benillouche, Raphael Lejoyeux, Ethan A. Rossi, Joshua Ong, Jay Chhablani, Kunal K. Dansingani, Susana da Silva, Debasish Sinha, Sumit Randhir Singh, Gerard A. Lutty |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Retinal pigment epithelium Choroid business.industry Disease spectrum Glaucoma Retinal Pigment Epithelium eye diseases Sensory Systems Ophthalmology medicine.anatomical_structure Retinal Diseases Humans Medicine sense organs Fluorescein Angiography business Tomography Optical Coherence |
| Zdroj: | Progress in Retinal and Eye Research. 87:100997 |
| ISSN: | 1350-9462 |
| Popis: | The choriocapillaris is the innermost structure of the choroid that directly nourishes the retinal pigment epithelium and photoreceptors. This article provides an overview of its hemovasculogenesis development to achieve its final architecture as a lobular vasculature, and also summarizes the current histological and molecular knowledge about choriocapillaris and its dysfunction. After describing the existing state-of-the-art tools to image the choriocapillaris, we report the findings in the choriocapillaris encountered in the most frequent retinochoroidal diseases including vascular diseases, inflammatory diseases, myopia, pachychoroid disease spectrum disorders, and glaucoma. The final section focuses on the development of imaging technology to optimize visualization of the choriocapillaris as well as current treatments of retinochoroidal disorders that specifically target the choriocapillaris. We conclude the article with pertinent unanswered questions and future directions in research for the choriocapillaris. |
| Databáze: | OpenAIRE |
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