Simultaneous determination of 137 drugs of abuse, new psychoactive substances, and novel synthetic opioids in meconium by UHPLC-QTOF
| Autor: | D. Di Corcia, Angelines Cruz-Landeira, Marta Massano, Ana de-Castro-Ríos, Alberto Salomone, Eleonora Amante, Ángela López-Rabuñal |
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| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Meconium Analyte media_common.quotation_subject NPS 01 natural sciences Biochemistry Analytical Chemistry Fentanyl 03 medical and health sciences 0302 clinical medicine medicine In Utero Drug Exposure media_common Detection limit In utero drug exposure Pregnancy 030219 obstetrics & reproductive medicine Chromatography business.industry 010401 analytical chemistry Acetylfentanyl medicine.disease 0104 chemical sciences QTOF business Research Paper medicine.drug |
| Zdroj: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) Analytical and Bioanalytical Chemistry |
| Popis: | New psychoactive substances (NPS) have been introduced into the market in recent years, with new analytes reported every year. The use of these substances in women can occur at any stage of life, even in the childbearing age. Drug use during pregnancy presents significant risks for the mother and the fetus, so it is important to have tools that allow to detect prenatal exposure to these substances of abuse. Therefore, an analytical method for the determination of 137 NPS and other drugs of abuse in meconium by UHPLC-QTOF was developed and validated for semi-quantitative purpose. Linearity range, limit of detection (LOD), precision, matrix effect, selectivity, and specificity were evaluated. For all analytes, the calibration curves were studied in the ranges between 2, 10, or 50 ng/g and 750 or 1000 ng/g, (depending on the analyte) and the LOD ranged between 0.04 and 2.4 ng/g. The method was applied to 30 meconium specimens from cases in which fentanyl had been administered as epidural anesthesia at the time of delivery or cases in which the maternal hair was positive to other drug of abuse. Four meconium samples tested positive for fentanyl (range concentration = 440–750 ng/g) and two samples tested positive to acetylfentanyl (range concentration = 190–1400 ng/g) A. López-Rabuñal would like to thank the Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, for her predoctoral contract (ED481A-2019/071) SI |
| Databáze: | OpenAIRE |
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