PROSTHESIS-ASSOCIATED PSEUDOMEMBRANE-INDUCED BONE RESORPTION
| Autor: | C. N. Hopson, A. M. Appel, S. W. Siverhus, Herman Jh, Wendy G. Sowder |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Necrosis Osteolysis medicine.medical_treatment Prosthesis Dinoprostone Bone resorption Rheumatology medicine Humans Pharmacology (medical) Bone Resorption Prostaglandin E2 Aged Aged 80 and over Membranes Tumor Necrosis Factor-alpha business.industry Histology Middle Aged medicine.disease Surgery Orthopedic surgery Calcium Female Hip Prosthesis medicine.symptom Foreign body business Interleukin-1 medicine.drug |
| Zdroj: | Rheumatology. 29:32-36 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | A pseudomembranous structure invariably develops at the cement-bone interface of implanted prostheses in association with aseptic loosening. The tissue has histological characteristics of a foreign body reaction presumably initiated by repetitive microtrauma-associated release of methacrylate cement and polyethylene wear debris. Explant cultures of pseudomembrane and synovial tissue derived from osteoarthritic patients undergoing revision for cemented hip implant failure have been shown to produce interleukin-1, tumour necrosis factor and prostaglandin E2, recognized mediators of bone resorption. Further, the conditioned media obtained from pseudomembrane cultures could directly effect bone resorption by inducing 45Ca release from prelabelled limb bone rudiments. Results implicate the prosthesis-associated pseudomembrane in the pathogenesis of the bone resorptive process responsible for prosthesis failure. |
| Databáze: | OpenAIRE |
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