Somatically recorded Ca-currents in guinea-pig hippocampal and olfactory cortex neurones are resistant to adenosine action
| Autor: | J.V. Halliwell, C.N. Scholfield |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Olfactory system
Adenosine Cell Membrane Permeability Guinea Pigs Rhinencephalon Hippocampus In Vitro Techniques Pharmacology Neurotransmission Hippocampal formation Biology Ion Channels Membrane Potentials Limbic System medicine Animals Channel blocker Cerebral Cortex General Neuroscience Olfactory Pathways Electrophysiology Calcium Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 50:13-18 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(84)90454-3 |
| Popis: | Inward membrane currents were recorded in tetrodotoxin-treated neurones of hippocampus and olfactory cortex in vitro after impalement with CsCl-containing microelectrodes to suppress potassium conductances. They were blocked by the Ca2+ -channel blocker Cd2+ but were unaffected by adenosine alone (up to 1 mM), adenosine (20 microM) in the presence of the uptake blocker dipyridamole (1 microM) or the stable analogue cyclohexyladenosine (100 microM). This ineffectiveness of adenosine on Ca-currents was in contrast to its known potent suppression of synaptic transmission in these preparations, and its inhibition of Ca-dependent action potentials. |
| Databáze: | OpenAIRE |
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