Evaluation of the 2-Aminomethylphenol JPC-2997 in Aotus Monkeys Infected with Plasmodium falciparum
| Autor: | Michael D. Edstein, Danielle I. Stanisic, Ivor Harris, Fiona J. McCallum, Karin van Breda, Sai Lata De, Michael F. Good, David P. Jacobus |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Pyridines 030106 microbiology Plasmodium falciparum Biology 03 medical and health sciences Antimalarials Phenols In vivo Chloroquine Mammalian cell parasitic diseases medicine Animals Pharmacology (medical) Malaria Falciparum Cytotoxicity Letters to the Editor Pharmacology Monkey Diseases biology.organism_classification medicine.disease Virology In vitro Infectious Diseases Aotidae Malaria falciparum Malaria medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 60(3) |
| ISSN: | 1098-6596 |
| Popis: | Previously, we reported JPC-2997 [4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol] to possess high in vitro antimalarial activity against Plasmodium falciparum lines, low cytotoxicity in mammalian cell lines, a long blood elimination half-life in Aotus monkeys (10.8 days), and potent in vivo efficacy against animal malaria models (1). Herein, as planned by Birrell et al., we report on the in vivo efficacy of JPC-2997 against the chloroquine- and quinine-resistant P. falciparum FVO strain in Aotus monkeys. |
| Databáze: | OpenAIRE |
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