Growth hormone treatment induces a dose-dependent catch-up growth in short children born small for gestational age: a summary of four clinical trials
| Autor: | Francis de Zegher, Otfrid Butenandt, Kerstin Albertsson-Wikland, Björn Jonsson, Patrick Wilton, Jean-Louis Chaussain, Annika Löfström |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Body height Endocrinology Diabetes and Metabolism Dose dependence Growth Short stature Endocrinology medicine Humans Child Dose-Response Relationship Drug business.industry Human Growth Hormone Human growth hormone Infant Newborn medicine.disease Body Height Growth hormone treatment Clinical trial Child Preschool Infant Small for Gestational Age Gh treatment Small for gestational age Regression Analysis Female medicine.symptom business |
| Zdroj: | Hormone research. 48 |
| ISSN: | 0301-0163 |
| Popis: | In the present study, data from 230 short children born small for gestational age, who were participating in four clinical trials, were pooled and analysed. At the start of GH treatment, median age and height SDS were 5.3 years and -3.2 SDS, respectively. A dose-dependent increase in height SDS was observed following 2 years of GH treatment: 1.1, 1.7 and 2.5 SDS for the three GH treatment groups (0.1, 0.2 and 0.3 IU/kg/day, respectively), compared with an increase of 0.14 SDS in the control group. In a multiple regression analysis, four variables were found to correlate independently with the gain in height SDS following 2 years of GH treatment. These are given below in order of importance: gain in height SDS = 7.7 x dose of GH (IU/kg/day) -0.11 x age (years) -0.08 x parental-adjusted height SDS + 0.05 x birth length SDS (SD = 0.5; r2 = 0.64). At the end of the 2-year study period, a total of 48%, 66% and 90% of patients in the groups given GH at 0.1, 0.2 and 0.3 IU/kg/day, respectively, had a parental-adjusted height greater than -1.0 SDS. |
| Databáze: | OpenAIRE |
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