DNA microarray integromics analysis platform
| Autor: | Tomasz Waller, Monika Piwowar, Wiktor Jurkowski, Krzysztof Sarapata, Tomasz Gubała |
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| Rok vydání: | 2014 |
| Předmět: |
DNA microarray analysis Platform
business.industry correlation analysis DNA microarray Computational biology Biology computer.software_genre Biochemistry Software Article Computer Science Applications Transcriptome Computational Mathematics Test case Computational Theory and Mathematics Lipidomics Genetics Data analysis Web application Microarray databases Data mining business Molecular Biology computer Gene |
| Zdroj: | BioData Mining |
| ISSN: | 1756-0381 |
| Popis: | The study of interactions between molecules belonging to different biochemical families (such as lipids and nucleic acids) requires specialized data analysis methods. This article describes the DNA Microarray Integromics Analysis Platform, a unique web application that focuses on computational integration and analysis of “multi-omics” data. Our tool supports a range of complex analyses, including – among others – low- and high-level analyses of DNA microarray data, integrated analysis of transcriptomics and lipidomics data and the ability to infer miRNA-mRNA interactions. We demonstrate the characteristics and benefits of the DNA Microarray Integromics Analysis Platform using two different test cases. The first test case involves the analysis of the nutrimouse dataset, which contains measurements of the expression of genes involved in nutritional problems and the concentrations of hepatic fatty acids. The second test case involves the analysis of miRNA-mRNA interactions in polysaccharide-stimulated human dermal fibroblasts infected with porcine endogenous retroviruses. The DNA Microarray Integromics Analysis Platform is a web-based graphical user interface for “multi-omics” data management and analysis. Its intuitive nature and wide range of available workflows make it an effective tool for molecular biology research. The platform is hosted at https://lifescience.plgrid.pl/ . |
| Databáze: | OpenAIRE |
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