Magnetofluorescent micellar complexes of terbium(III) as potential bimodal contrast agents for magnetic resonance and optical imaging
| Autor: | Sophie Laurent, Sophie Carron, Luce Vander Elst, Tatjana N. Parac-Vogt, Michael Harris, Robert N. Muller |
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| Rok vydání: | 2015 |
| Předmět: |
Lanthanide
Magnetic moment Chemistry Metals and Alloys chemistry.chemical_element Terbium General Chemistry Micelle Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Ion chemistry.chemical_compound Nuclear magnetic resonance Amphiphile Materials Chemistry Ceramics and Composites DOTA Rotational correlation time |
| Zdroj: | Chemical communications (Cambridge, England). 51(14) |
| ISSN: | 1364-548X |
| Popis: | Terbium(III) was coordinated to four novel 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) amphiphilic bisamide ligands. The complexes were assembled into mono-disperse micellar nano-aggregates and for the first time Tb(III) has been evaluated as a single lanthanide negative bimodal contrast agent for MRI/OI. The complexes show characteristic Tb(III) emission with quantum yields reaching 7.3% and transverse relaxivity r2 per Tb(III) micelle at 500 MHz and 310 K reaches maximum values up to 60 s(-1) micelle(-1). The efficient T2 relaxation at high magnetic field strengths is sustained by the increased rotational correlation time of the nano-aggregates and high magnetic moment of the terbium ion. |
| Databáze: | OpenAIRE |
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