Ubiquitin-Dependent Protein Degradation
| Autor: | Stefan Jentsch, Thomas Sommer, Sebastian Springer, Hans-Peter Hauser, Stephan Schlenker, Wolfgang Seufert, Joern Jungmann, Ruth Heinlein |
|---|---|
| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | DNA Replication and the Cell Cycle ISBN: 9783642770425 Protein Synthesis and Targeting in Yeast ISBN: 9783642849237 |
| DOI: | 10.1007/978-3-642-77040-1_14 |
| Popis: | Intracellular protein levels are controlled by protein synthesis and degradation. One major proteolytic pathway of eukaryotes requires the covalent attachment of ubiquitin, a small (8.5 kDa) and highly conserved protein, to proteolytic substrates prior to degradation (for reviews see Hershko 1991, Finley and Chau 1991, Jentsch et al. 1991, Jentsch 1992a, Jentsch 1992b). This pathway is highly selective and mediates the elimination of abnormal proteins and controls the half-lives of some regulatory proteins. Known targets include transcriptional regulators (Hochstrasser et al. 1991) p53 (Scheffner et al. 1990) and cyclins (Glotzer et al. 1991). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|