MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold
| Autor: | André C. Carpentier, Norman B. Konyer, Elizabeth Gunn, Zubin Punthakee, Basma A. Ahmed, Nina P. Singh, Michael D. Noseworthy, Katherine M. Morrison, Gregory R. Steinberg, Frank J. Ong, François Haman, Denis P. Blondin, Stephan Oreskovich |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism T2 cold exposure Cold exposure Context (language use) PDFF Body fat percentage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Brown adipose tissue medicine Lipolysis Clinical Research Articles 2. Zero hunger Obesity and Adipocyte Biology business.industry brown adipose tissue 030104 developmental biology medicine.anatomical_structure Endocrinology Time course Posterior neck region business Body mass index MRI |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/js.2019-00309 |
| Popis: | Context In rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined. Objective To determine the time course of BAT activation and changes in intracellular TAG using MRI assessment of the SCV (i.e., BAT depot) and fat in the posterior neck region (i.e., non-BAT). Design Cross-sectional. Setting Clinical research center. Patients or Other Participants Twelve healthy male volunteers aged 18 to 29 years [body mass index = 24.7 ± 2.8 kg/m2 and body fat percentage = 25.0% ± 7.4% (both, mean ± SD)]. Intervention(s) Standardized whole-body cold exposure (180 minutes at 18°C) and immediate rewarming (30 minutes at 32°C). Main Outcome Measure(s) Proton density fat fraction (PDFF) and T2* of the SCV and posterior neck fat pads. Acquisitions occurred at 5- to 15-minute intervals during cooling and subsequent warming. Results SCV PDFF declined significantly after only 10 minutes of cold exposure [−1.6% (SE: 0.44%; P = 0.007)] and continued to decline until 35 minutes, after which time it remained stable until 180 minutes. A similar time course was also observed for SCV T2*. In the posterior neck fat (non-BAT), there were no cold-induced changes in PDFF or T2*. Rewarming did not result in a change in SCV PDFF or T2*. Conclusions The rapid cold-induced decline in SCV PDFF suggests that in humans BAT is activated quickly in response to cold and that TAG is a primary substrate. |
| Databáze: | OpenAIRE |
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