Failure of genetically selected miniature swine to model NIDDM
| Autor: | J. Rodin, M. S. Hand, P. Van Order, Richard S. Surwit, Mark N. Feinglos |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Swine Endocrinology Diabetes and Metabolism Miniature swine Impaired glucose tolerance Animal model Internal medicine Diabetes mellitus Intravenous insulin medicine Internal Medicine Animals Insulin Oral glucose tolerance business.industry Insulin sensitivity Glucose Tolerance Test medicine.disease Diet Regimen Disease Models Animal Endocrinology Diabetes Mellitus Type 2 Swine Miniature Female business |
| Zdroj: | Diabetes. 36:284-287 |
| ISSN: | 0012-1797 |
| Popis: | Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic diet; and 4 mo of excess diabetogenic diet for obesification. Results of oral glucose tolerance and intravenous insulin tolerance tests conducted at the end of each regimen were compared. Hyperglycemia was not observed in any animals after any manipulation. Insulin sensitivity was also not influenced by diet. We conclude that F7 low-K miniature swine from this colony fail to model human non-insulin-dependent diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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