Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141
| Autor: | Peter Tomasec, Gavin William Grahame Wilkinson, Akio Nomoto, Sian Llewellyn-Lacey, Edward Chung Yern Wang, Borivoj Vojtesek, Melanie Armstrong, Andrew J. Davison, Carole R. Rickards, Brian P. McSharry, Rebecca J. Morris, Cora Griffin, Christian Sinzger |
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| Rok vydání: | 2004 |
| Předmět: |
Human cytomegalovirus
CD96 CD226 Immunology Cytomegalovirus Down-Regulation Biology Ligands Article Natural killer cell Interleukin 21 Viral Proteins medicine Immunology and Allergy Humans Cells Cultured Glycoproteins Lymphokine-activated killer cell Membrane Proteins medicine.disease Cell biology Killer Cells Natural Cell killing medicine.anatomical_structure Cell culture Cytomegalovirus Infections Mutation Receptors Virus |
| Zdroj: | Nature immunology. 6(2) |
| ISSN: | 1529-2908 |
| Popis: | Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function. |
| Databáze: | OpenAIRE |
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