Sex differences in mitochondrial respiratory function in human skeletal muscle
| Autor: | Tanya M. Holloway, Chris McGlory, Stuart M. Phillips, Paula M. Miotto, Graham P. Holloway |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Bioenergetics Physiology Cellular respiration Mitochondrion Biology 03 medical and health sciences Young Adult Absorptiometry Photon Oxygen Consumption Physiology (medical) Internal medicine medicine Humans Respiratory function Muscle Skeletal Adiposity Sex Characteristics Rapid Report Skeletal muscle Lipid metabolism Metabolism Aerobiosis Mitochondria Muscle Adenosine Diphosphate Kinetics 030104 developmental biology medicine.anatomical_structure Endocrinology Female Energy Metabolism |
| Popis: | Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle metabolism remain poorly defined. The primary aim of this study was to determine whether mitochondrial respiratory kinetics differed between healthy young men and women in permeabilized skeletal muscle fibers. While men and women displayed similar ( P > 0.05) maximal respiration rates and abundance of mitochondrial/adenosine diphosphate (ADP) transport proteins, women had lower ( P < 0.05) mitochondrial ADP sensitivity (+30% apparent Km) and absolute respiration rates at a physiologically relevant ADP concentration (100 μM). Moreover, although men and women exhibited similar carnitine palmitoyl transferase-I protein content- and palmitoyl-CoA-supported respiration, women displayed greater sensitivity to malonyl-CoA-mediated respiratory inhibition. These data establish baseline sex differences in mitochondrial bioenergetics and provide the foundation for studying mitochondrial function within the context of metabolic perturbations and diseases that affect men and women differently. |
| Databáze: | OpenAIRE |
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