Immune Complexes in Cystic Fibrosis
| Autor: | J. D. Allan, P. Brenchley, H McFarlane, B. Worsley, J. C. Wallwork, A Holzel, B. E. Singer |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Immunoglobulin A Antigen-Antibody Complex Cystic Fibrosis Staphylococcus Respiratory System Serum albumin Fluorescent Antibody Technique Cystic fibrosis Antibodies Immunoglobulin G Hemolysin Proteins Immune system medicine Humans Bovine serum albumin Child Immunoelectrophoresis Lung General Environmental Science biology Sputum General Engineering Infant Serum Albumin Bovine Papers and Originals Complement System Proteins General Medicine biochemical phenomena metabolism and nutrition medicine.disease Precipitin Tests Immunoglobulin M Child Preschool Immunology Chromatography Gel biology.protein Autoradiography General Earth and Planetary Sciences Female Adsorption Antibody Digestive System |
| Zdroj: | BMJ. 1:423-428 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.1.5955.423 |
| Popis: | Circulating immune complexes were detected in serum and sputum of patients with cystic fibrosis (C.F.). There were extensive deposits of immunoglobulins and complement immune complexes in several of the C.F. organs, especially the respiratory and gastrointestinal tracts, but not in the kidneys. Significant concentrations of IgG and of complement complexes could be eluted from the lungs of the C.F. patients but not from those of controls. Studies involving immunoabsorption, autoradiography, and molecular sieving through Sephadex G-200 columns identified both bovine serum albumin and staphylococcal alpha-haemolysin as two of the antigens present in the immune complexes. The sedimentation constant of the immune complexes was about 8S to 11S. The clinical significance of these immune complexes and the wide variety of antibodies detected in C.F. patients are discussed. |
| Databáze: | OpenAIRE |
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