Stem cell death and survival in heart regeneration and repair
| Autor: | Audrone Kalvelyte, Katherine Athayde Teixeira de Carvalho, Luiz Cesar Guarita-Souza, Gabor Foldes, Aurimas Stulpinas, Eltyeb Abdelwahid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Clinical Biochemistry Myocardial Infarction Pharmaceutical Science Apoptosis Stem cells Exosomes Bioinformatics Myocytes Cardiac OXIDATIVE STRESS Induced pluripotent stem cell IN-VIVO PRESERVES CARDIAC-FUNCTION Heart Stem-cell therapy Cell biology Ischemic Preconditioning Myocardial Stem cell RECEPTOR-STIMULATED APOPTOSIS Life Sciences & Biomedicine Signal Transduction Pluripotent Stem Cells Cell death Cell type Biochemistry & Molecular Biology ACUTE MYOCARDIAL-INFARCTION Cell Survival BONE-MARROW Bioengineering Biology Article DEPRIVATION-INDUCED APOPTOSIS 03 medical and health sciences medicine Animals Humans Regeneration PROTEIN-KINASE-B Pharmacology Science & Technology Multipotent Stem Cells Regeneration (biology) Biochemistry (medical) ISCHEMIC-HEART 0601 Biochemistry And Cell Biology Genetic Therapy Cell Biology medicine.disease Transplantation MicroRNAs 030104 developmental biology Multipotent Stem Cell Heart failure 1116 Medical Physiology Therapy SIGNAL-TRANSDUCTION PATHWAYS Reactive Oxygen Species |
| Popis: | Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell survival in the heart has significant therapeutic implications. Cardiac tissue has limited capacity to regenerate and repair. Stem cell therapy is a successful approach for repairing and regenerating ischemic cardiac tissue; however, transplanted cells display very high death percentage, a problem that affects success of tissue regeneration. Stem cells display multipotency or pluripotency and undergo self-renewal, however these events are negatively influenced by upregulation of cell death machinery that induces the significant decrease in survival and differentiation signals upon cardiovascular injury. While efforts to identify cell types and molecular pathways that promote cardiac tissue regeneration have been productive, studies that focus on blocking the extensive cell death after transplantation are limited. The control of cell death includes multiple networks rather than one crucial pathway, which underlies the challenge of identifying the interaction between various cellular and biochemical components. This review is aimed at exploiting the molecular mechanisms by which stem cells resist death signals to develop into mature and healthy cardiac cells. Specifically, we focus on a number of factors that control death and survival of stem cells upon transplantation and ultimately affect cardiac regeneration. We also discuss potential survival enhancing strategies and how they could be meaningful in the design of targeted therapies that improve cardiac function. |
| Databáze: | OpenAIRE |
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