Reduced Information Transmission of Medial Prefrontal Cortex to Basolateral Amygdala Inhibits Exploratory Behavior in Depressed Rats
| Autor: | Xuyuan Zheng, Wenwen Bai, Tiaotiao Liu, Zihe Wang, Chengxi Qi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Local field potential
Direct transfer local field potentials behavioral disciplines and activities Open field lcsh:RC321-571 Medicine Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Depression (differential diagnoses) Original Research Information transmission information flow business.industry musculoskeletal neural and ocular physiology General Neuroscience Significant difference biochemical phenomena metabolism and nutrition medicine.anatomical_structure nervous system depression business Neuroscience psychological phenomena and processes medial prefrontal cortex basolateral amygdala Basolateral amygdala |
| Zdroj: | Frontiers in Neuroscience, Vol 14 (2020) Frontiers in Neuroscience |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2020.608587 |
| Popis: | Depression is a mental and neurological disease that reduces the desire for exploration. Dysregulation of the information transmission between medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) is associated with depression. However, which direction of information transmission (mPFC-BLA or BLA-mPFC) related to the decline of exploratory interests in depression is unclear. Therefore, it is important to determine what specific changes occur in mPFC and BLA information transmission in depressed rats during exploratory behavior. In the present study, local field potentials (LFPs) were recorded via multi-electrodes implanted in the mPFC and BLA for the control and depression groups of rats when they were exploring in an open field. The theta band was determined to be the characteristic band of exploratory behavior. The direct transfer function (DTF) was used to calculate the mPFC and BLA bidirectional information flow (IF) to measure information transmission. Compared with the control group, the theta IF of mPFC-BLA in the depression group was significantly reduced, and there was no significant difference in theta IF of BLA-mPFC between the two groups. Our results indicated that the reduction of mPFC-BLA information transmission can inhibit the exploratory behavior of depressed rats. |
| Databáze: | OpenAIRE |
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