Intra‐ and Intermolecular Nickel‐Catalyzed Reductive Cross‐Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides
| Autor: | Luke E. Hanna, Elizabeth R. Jarvo, Mikhail O. Konev |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry Aryl Intermolecular force Halide General Medicine General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis Coupling reaction 3. Good health 0104 chemical sciences chemistry.chemical_compound Stereospecificity Intramolecular force Electrophile Organic chemistry |
| Zdroj: | Angewandte Chemie International Edition. 55:6730-6733 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201601206 |
| Popis: | Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described. |
| Databáze: | OpenAIRE |
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