Role of acid tolerance response genes in Salmonella typhimurium virulence
| Autor: | B. Brett Finlay, J W Foster, F Garcia-del Portillo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Salmonella typhimurium
Salmonella Immunology Mutant Virulence Mutagenesis (molecular biology technique) Biology medicine.disease_cause Microbiology Mice Dogs Bacterial Proteins medicine Animals Humans Typhoid Fever Gene Mice Inbred BALB C Hydrogen-Ion Concentration biology.organism_classification Enterobacteriaceae Repressor Proteins Mutagenesis Insertional Proton-Translocating ATPases Infectious Diseases Genes Bacterial bacteria Parasitology Intracellular Bacteria HeLa Cells Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.61.10.4489-4492.1993 |
| Popis: | The atp and fur genes are involved in the acid tolerance response of Salmonella typhimurium. An atp::Tn10 mutant was avirulent in the mouse typhoid model when assayed by oral and intraperitoneal routes. However, a fur mutant was completely virulent by the intraperitoneal route. No relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells. These data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence. |
| Databáze: | OpenAIRE |
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