Pathophysiological relevance of the cardiac β2-adrenergic receptor and its potential as a therapeutic target to improve cardiac function
| Autor: | Joaquín Pérez-Schindler, Jesús Hernández-Cascales, Andrew Philp |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Cardiac function curve medicine.medical_specialty business.industry Myocardium Adrenergic Arrhythmias Cardiac Heart Stimulation medicine.disease Contractility Internal medicine Heart failure cardiovascular system Cardiology Animals Humans Medicine Myocyte Myocytes Cardiac Molecular Targeted Therapy Receptors Adrenergic beta-2 business Receptor Heart metabolism |
| Zdroj: | European Journal of Pharmacology. 698:39-47 |
| ISSN: | 0014-2999 |
| Popis: | β-adrenoceptors are members of the G protein-coupled receptor superfamily which play a key role in the regulation of myocardial function. Their activation increases cardiac performance but can also induce deleterious effects such as cardiac arrhythmias or myocardial apoptosis. In fact, inhibition of β-adrenoceptors exerts a protective effect in patients with sympathetic over-stimulation during heart failure. Although β(2)-adrenoceptor is not the predominant subtype in the heart, it seems to importantly contribute to the cardiac effects of adrenergic stimulation; however, the mechanism by which this occurs is not fully understood. This review summarizes the current knowledge on the role of β(2)-adrenoceptors in the regulation of cardiac contractility, metabolism, cardiomyocyte survival and cardiac arrhythmias. In addition, therapeutic considerations relating to stimulation of the β(2)-adrenoceptor such as an increase in cardiac contractility with low arrythmogenic effect, protection of the myocardium again apoptosis or positive regulation of heart metabolism are discussed. |
| Databáze: | OpenAIRE |
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