Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging
| Autor: | David Freitas de Lucena, Letícia Sanguinetti Czepielewski, Florencia María Barbé-Tuana, Danielle Silveira Macêdo, Eduarda Dias da Rosa, Lucas Kich Grun, Bruna Panizzutti, Raffael Massuda, Clarissa Severino Gama |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Adolescent Endophenotypes Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Interview Psychological medicine Humans Bipolar disorder Young adult Pathological Telomere Shortening Biological Psychiatry Psychiatric Status Rating Scales Genetics Analysis of Variance Siblings Middle Aged Telomere medicine.disease Pathophysiology 030227 psychiatry Psychiatry and Mental health Endocrinology Schizophrenia Endophenotype Educational Status Biomarker (medicine) Female Analysis of variance Psychology 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Schizophrenia Research. 174:39-42 |
| ISSN: | 0920-9964 |
| Popis: | Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (SB, n=36) and healthy controls (HC, n=47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations. |
| Databáze: | OpenAIRE |
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