Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Autor: Willeke F. Daamen, Michiel W. Pot, Toin H. van Kuppevelt, Ghislaine Gayan-Ramirez, Danique J. Hof, Lucie Hympanova, Mary Patrice Eastwood, Eric Verbeken, Rita Rynkevic, Luc Joyeux, Jan Deprest, Savitree Pranpanus
Rok vydání: 2017
Předmět:
Male
Scaffold
Foreign-body giant cell
medicine.medical_specialty
Swine
Biomedical Engineering
Medicine (miscellaneous)
Diaphragmatic breathing
pore orientation
Biomaterials
03 medical and health sciences
0302 clinical medicine
All institutes and research themes of the Radboud University Medical Center
030225 pediatrics
Medicine
Animals
Humans
Diaphragmatic hernia
defect repair
Herniorrhaphy
Hernia
Diaphragmatic
Rib cage
Tissue Scaffolds
business.industry
Foreign-Body Reaction
diaphragmatic hernia
collagen scaffold
Rabbit (nuclear engineering)
medicine.disease
3. Good health
Diaphragm (structural system)
Surgery
Compliance (physiology)
Disease Models
Animal
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
030220 oncology & carcinogenesis
Collagen
Rabbits
business
Zdroj: Journal of Tissue Engineering and Regenerative Medicine, 12, 11, pp. 2138-2150
Journal of Tissue Engineering and Regenerative Medicine, 12, 2138-2150
ISSN: 1932-7005
1932-6254
Popis: Gore-Tex® is a widely used durable patch for repair of congenital diaphragmatic defects yet may result in complications. We compared Gore-Tex with a composite of a radial pore-orientated collagen scaffold (RP-Composite) and clinically used porcine small intestinal submucosa (SIS; Surgisis®) in a rabbit model for diaphragmatic hernia. The growing rabbit mimics the rapid rib cage growth and reherniation rates seen in children. We created and immediately repaired left hemidiaphragmatic defects in 6-week-old rabbits with Gore-Tex, SIS, and an RP-Composite scaffold. An additional group of rabbits had a sham operation. At 90 days, survivors more than doubled in weight. We observed few reherniations or eventrations in Gore-Tex (17%) and RP-Composite (22%) implanted animals. However, SIS failed in all rabbits. Maximum transdiaphragmatic pressure was lower in Gore-Tex (71%) than RP-Composite implanted animals (112%) or sham (134%). Gore-Tex repairs were less compliant than RP-Composite, which behaved as sham diaphragm (p
Databáze: OpenAIRE
Externí odkaz: