Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats
| Autor: | Shu-wen Yu, Hong-Xiang Lou, Anchang Liu, Li-Xia Zhao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Ticlopidine Vasodilator Agents Herb-Drug Interactions Pharmacology Drug Administration Schedule chemistry.chemical_compound Pharmacokinetics Tandem Mass Spectrometry Puerarin Drug Discovery medicine Animals cardiovascular diseases Rats Wistar business.industry Warfarin Anticoagulants General Medicine Drug interaction Isoflavones Clopidogrel Rats Complementary and alternative medicine chemistry Platelet aggregation inhibitor business Injections Intraperitoneal Platelet Aggregation Inhibitors Chromatography Liquid circulatory and respiratory physiology medicine.drug |
| Zdroj: | Chinese Journal of Natural Medicines. 13:257-263 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(15)30012-1 |
| Popis: | The present study was designed to determine the effects of puerarin pre-treatment on the pharmacokinetics of the oral anticoagulant agent warfarin and the antiplatelet agent clopidogrel in rats. In the treatment group, rats was gavaged with warfarin or clopidogrel after repeated treatment with puerarin at intraperitoneal doses of 20, 60, or 200 mg·kg(-1) for 7 days, while rats in the control group were administrated only with the same dose warfarin or clopidogrel. Plasma samples were obtained at the prescribed times and analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS). The results showed that rats treated with puerarin at all the test doses of 20, 60 and 200 mg·kg(-1) were found to affect the pharmacokinetics of warfarin, but not clopidogrel, suggesting a potential herb-drug interaction between puerarin and warfarin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect