Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis
| Autor: | Philippe Saas, Daniel Wendling, Nhu Uyen Nguyen, Gilles Dumoulin, Eric Toussirot, Gérald Streit, Gaëlle Le Huédé |
|---|---|
| Přispěvatelé: | Agents pathogènes et inflammation - UFC (EA 4266) ( API ), Université de Franche-Comté ( UFC ), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( PCVP / CARDIO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
MESH: Inflammation Peptide Hormones Endocrinology Diabetes and Metabolism MESH : Cytokines MESH: Insulin-Like Growth Factor I MESH : Spondylitis Ankylosing Adipose tissue MESH : Insulin-Like Growth Factor I MESH: Eating Eating Absorptiometry Photon Anabolic Agents MESH: Hormones 0302 clinical medicine Endocrinology Medicine MESH : Female MESH : Anabolic Agents Insulin-Like Growth Factor I MESH: Cytokines 0303 health sciences MESH: Middle Aged Leptin digestive oral and skin physiology Middle Aged MESH : Adult MESH : Hormones MESH: Spondylitis Ankylosing Ghrelin MESH: Motor Activity Adipose Tissue [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Body Composition Cytokines Female Tumor necrosis factor alpha MESH: Adipose Tissue hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty MESH : Eating MESH : Male MESH : Body Composition MESH: Ghrelin Adipokine MESH: Absorptiometry Photon Motor Activity MESH : Adipose Tissue [ SDV.MHEP.RSOA ] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system 03 medical and health sciences Internal medicine Humans Spondylitis Ankylosing MESH : Middle Aged Spondylitis 030304 developmental biology MESH : Absorptiometry Photon Inflammation 030203 arthritis & rheumatology Ankylosing spondylitis MESH: Humans MESH : Inflammation Adiponectin business.industry MESH : Humans MESH: Anabolic Agents MESH: Adult MESH: Body Composition medicine.disease MESH : Ghrelin Hormones MESH: Male MESH : Peptide Hormones MESH: Peptide Hormones business MESH: Female MESH : Motor Activity |
| Zdroj: | Metabolism Metabolism, WB Saunders, 2007, 56 (10), pp.1383-9. 〈10.1016/j.metabol.2007.05.009〉 Metabolism, Elsevier, 2007, 56 (10), pp.1383-9. ⟨10.1016/j.metabol.2007.05.009⟩ |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2007.05.009〉 |
| Popis: | International audience; Adipokines such as leptin and adiponectin are involved in the regulation of inflammation. Ghrelin, a gastric peptide playing a role in the appetite regulation, possesses anti-inflammatory properties. In this study, we evaluated the circulating levels of adipokines (leptin as potential proinflammatory and adiponectin as anti-inflammatory marker) and ghrelin and the fat mass in patients with ankylosing spondylitis (AS). Serum leptin, adiponectin, and ghrelin were evaluated in 53 AS patients with active disease (mean Bath Ankylosing Spondylitis Disease Activity Index >40) and 35 controls. Fat and lean masses were determined using dual-energy x-ray absorptiometry. Fat and lean masses did not differ between patients and controls. Ankylosing spondylitis patients had lower leptin levels compared with controls, even after adjustment for fat mass (AS vs controls: leptin, 7.6 +/- 1.3 ng/mL vs 10.3 +/- 1.5 ng/mL; leptin [in nanograms per milliliter]/fat mass [in kilograms], 0.28 +/- 0.04 vs 0.44 +/- 0.04; P = .006 and P = .0003, respectively). Serum adiponectin did not differ between patients and controls, whereas circulating ghrelin was higher in AS patients (1354.6 +/- 70.5 pg/mL vs 1008.0 +/- 82.5 pg/mL; P = .001). However, all these results were significant only for male patients. No correlation was found between leptin and adiponectin, and erythrocyte sedimentation rate, C-reactive protein levels, tumor necrosis factor alpha, or Bath Ankylosing Spondylitis Disease Activity Index. Ankylosing spondylitis patients had no changes in fat mass. Leptin production was reduced in contrast with normal levels of adiponectin. These adipokine results, together with high serum ghrelin levels, may influence the inflammatory response in AS. |
| Databáze: | OpenAIRE |
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