In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells
| Autor: | Afia Usman, Shoeb Ikhlas, Masood Ahmad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine endocrine system Bisphenol A Cell Survival Oxidative phosphorylation Pharmacology Toxicology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phenols medicine Humans Benzhydryl Compounds Cytotoxicity Cells Cultured chemistry.chemical_classification Reactive oxygen species urogenital system General Medicine Glutathione Comet assay Oxidative Stress 030104 developmental biology chemistry 030220 oncology & carcinogenesis Leukocytes Mononuclear Comet Assay Reactive Oxygen Species hormones hormone substitutes and hormone antagonists Oxidative stress Genotoxicity DNA Damage Mutagens |
| Zdroj: | Toxicology in Vitro. 60:229-236 |
| ISSN: | 0887-2333 |
| DOI: | 10.1016/j.tiv.2019.06.001 |
| Popis: | Although Bisphenol-A (BPA) has been found to exhibit toxicological properties such as genotoxicity and oxidative stress, yet there is very little data available on its analogues. Since the replacement of BPA by its analogues, their presence has been found to increase in the environment leading to increased human exposure that makes it essential to investigate their toxic effects. Therefore, we explored the genotoxic and oxidative potential of two common BPA analogues, Bisphenol-B (BPB) and Bisphenol-F (BPF). Both analogues were found to induce cytotoxicity in human peripheral blood cells. They also caused an increase in reactive oxygen species levels leading to a decrease in GSH and an increase in LPO levels. Comet assay also suggested them to be genotoxic. Therefore, bisphenols were found capable of inducing cytotoxicity via oxidative stress and genotoxicity. |
| Databáze: | OpenAIRE |
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