The High Energy Cost of Theta–Gamma Activity during REM Sleep
| Autor: | Anusha Mishra, Laura Lee Colgin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
High energy Sleep REM Hippocampus Rodentia Electroencephalography Article 03 medical and health sciences 0302 clinical medicine Animals Gamma Rhythm Medicine Theta Rhythm Wakefulness medicine.diagnostic_test business.industry General Neuroscience Brain Sleep in non-human animals Rats 030104 developmental biology Energy expenditure Sleep Neurovascular coupling business Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications |
| ISSN: | 0166-2236 |
| DOI: | 10.1016/j.tins.2019.02.004 |
| Popis: | Rapid eye movement sleep (REMS) is a peculiar brain state combining the behavioral components of sleep and the electrophysiological profiles of wake. After decades of research our understanding of REMS still is precluded by the difficulty to observe its spontaneous dynamics and the lack of multimodal recording approaches to build comprehensive datasets. We used functional ultrasound (fUS) imaging concurrently with extracellular recordings of local field potentials (LFP) to reveal brain-wide spatiotemporal hemodynamics of single REMS episodes. We demonstrate for the first time the close association between global hyperemic events – largely outmatching wake levels in most brain regions – and local hippocampal theta (6–10 Hz) and fast gamma (80–110 Hz) events in the CA1 region. In particular, the power of fast gamma oscillations strongly correlated with the amplitude of subsequent vascular events. Our findings challenge our current understanding of neurovascular coupling and question the evolutionary benefit of such energy-demanding patterns in REMS function. Neural activity during REM sleep is similar to the waking state. Here, the authors measure blood volume with neurofunctional ultrasound imaging together with hippocampal neural activity during REM sleep and report that fast gamma oscillations are coupled to a brain-wide upregulation of vascular flow. |
| Databáze: | OpenAIRE |
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