Evidence for intestinal oxidative stress in patients with obstructive jaundice
| Autor: | Konstantinos Thomopoulos, Christos D. Georgiou, Constantine E Vagianos, Vassiliki N Nikolopoulou, Stelios F Assimakopoulos, Chrisoula D. Scopa, Nikolaos Patsoukis |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pathology Duodenum Clinical Biochemistry Oxidative phosphorylation medicine.disease_cause Biochemistry Gastroenterology Lipid peroxidation chemistry.chemical_compound Intestinal mucosa Malondialdehyde Internal medicine medicine Humans Intestinal Mucosa Aged Lamina propria Cholestasis Glutathione Disulfide business.industry Proteins General Medicine Glutathione Jaundice Jaundice Obstructive Oxidative Stress medicine.anatomical_structure Bile Duct Neoplasms chemistry Female Lipid Peroxidation medicine.symptom business Oxidation-Reduction Oxidative stress |
| Zdroj: | European Journal of Clinical Investigation. 36:181-187 |
| ISSN: | 1365-2362 0014-2972 |
| Popis: | Background Obstructive jaundice results in failure of the intestinal barrier with consequent systemic endotoxemia associated with septic complications. We have recently shown that gut barrier failure in experimental obstructive jaundice is associated with high intestinal oxidative stress. This study was undertaken to investigate whether oxidative alterations occur in the intestinal mucosa of patients with obstructive jaundice. Patients and methods Fifteen patients with malignant biliary obstruction and no signs of cholangitis and 15 control patients were subjected to duodenal biopsy to assess intestinal oxidative stress, estimated by lipid peroxidation (malondialdehyde – MDA) and glutathione redox state [reduced glutathione (GSH), glutathione disulphide (GSSG) and GSH/GSSG ratio]. In addition, mucosal biopsies were examined histologically and intestinal mucosal protein content was determined biochemically as an index of intestinal trophic state. Results Patients with obstructive jaundice presented high levels of intestinal oxidative stress, with significantly increased lipid peroxidation (P |
| Databáze: | OpenAIRE |
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