Pharyngeal arch patterning in the absence of neural crest
| Autor: | Thomas F. Schilling, Anthony Graham, Jo Begbie, Emma Veitch, Moya M. Smith |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Genetic Markers
Fibroblast Growth Factor 8 Bone Morphogenetic Protein 7 Chick Embryo Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Cranial neural crest Transforming Growth Factor beta Pharyngeal apparatus medicine Animals Paired Box Transcription Factors Hedgehog Proteins Process (anatomy) Face and neck development of the embryo In Situ Hybridization 030304 developmental biology Body Patterning 0303 health sciences Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Neural crest Gene Expression Regulation Developmental Proteins Anatomy Biological Evolution DNA-Binding Proteins Fibroblast Growth Factors medicine.anatomical_structure Branchial Region Neural Crest Bone Morphogenetic Proteins Trans-Activators Head morphogenesis Crest General Agricultural and Biological Sciences 030217 neurology & neurosurgery Pharyngeal arch Transcription Factors |
| Zdroj: | Current biology : CB. 9(24) |
| ISSN: | 0960-9822 |
| Popis: | Pharyngeal arches are a prominent and critical feature of the developing vertebrate head. They constitute a series of bulges within which musculature and skeletal elements form; importantly, these tissues derive from different embryonic cell types [1]. Numerous studies have emphasised the role of the cranial neural crest, from which the skeletal components derive, in patterning the pharyngeal arches [2–4]. It has never been clear, however, whether all arch patterning is completely dependent on this cell type. Here, we show that pharyngeal arch formation is not coupled to the process of crest migration and, furthermore, that pharyngeal arches form, are regionalised and have a sense of identity even in the absence of the neural crest. Thus, vertebrate head morphogenesis can now be seen to be a more complex process than was previously believed and must result from an integration of both neural-crest-dependent and -independent patterning mechanisms. Our results also reflect the fact that the evolutionary origin of pharyngeal segmentation predates that of the neural crest, which is an exclusively vertebrate characteristic. |
| Databáze: | OpenAIRE |
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